acute myeloid leukemia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6S1435	Notopterol		Apoptosis , Others
	1. Notopterol induces apoptosis and inhibits cell cycle-specific.		Apoptosis , Others
T13950	UC-514321		Apoptosis , STAT
	UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.		Apoptosis , STAT
T12253	Nrf2-IN-1		Others , Nrf2
	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).		Others , Nrf2
T7138	FB23-2		Apoptosis , Others
	FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM).		Apoptosis , Others
T12943	SNDX-5613		Epigenetic Reader Domain , Histone Methyltransferase
	SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.		Epigenetic Reader Domain , Histone Methyltransferase
T9041	AES-350		Apoptosis , HDAC
	AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, ...		Apoptosis , HDAC
T10606	BRD0705		GSK-3
	BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM).		GSK-3
T9705	TL-895		BTK
	TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM.		BTK
T16557	PNU-159682		Topoisomerase
	PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin.		Topoisomerase
T14919	CDKI-73		Apoptosis , CDK
	CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effe...		Apoptosis , CDK
T38562	AKN-028		FLT
	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.		FLT
T2620	G-749	G749	Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
	G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.		Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
T10384	Farudodstat	ASLAN003	Apoptosis , Dehydrogenase , DNA/RNA Synthesis
	Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML.		Apoptosis , Dehydrogenase , DNA/RNA Synthesis
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T1882	Meisoindigo	N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III	Apoptosis
	Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).		Apoptosis
T1979	AVN-944	VX-944	Dehydrogenase
	AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.		Dehydrogenase
T2066	Quizartinib	AC220	Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC
	Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T0942	Quinacrine dihydrochloride	Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl	Apoptosis , Mitophagy , DNA , Phospholipase , Parasite , Autophagy , Histamine Receptor
	Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T2346L	Enasidenib mesylate	AG221 mesylate,AG 221 mesylate,AG-221 mesylate	Dehydrogenase
	Enasidenib mesylate (AG-221 mesylate) is a potent and selective IDH2 mutase inhibitor that promotes differentiation of leukemia myeloid cells for the treatment of acute myeloid leukemia.		Dehydrogenase
T3099	Pinometostat	EPZ-5676	Histone Methyltransferase
	Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others.		Histone Methyltransferase